Protein aggregation profile of the human kinome
نویسندگان
چکیده
منابع مشابه
Protein aggregation profile of the human kinome
Protein aggregation into amyloid fibrils is associated with the onset of an increasing number of human disorders, including Alzheimer's disease, diabetes, and some types of cancer. The ability to form toxic amyloids appears to be a property of most polypeptides. Accordingly, it has been proposed that reducing aggregation and its effect in cell fitness is a driving force in the evolution of prot...
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Human protein kinases play fundamental roles mediating the majority of signal transduction pathways in eukaryotic cells as well as a multitude of other processes involved in metabolism, cell-cycle regulation, cellular shape, motility, differentiation and apoptosis. The human protein kinome contains 518 members. Most studies that focus on the human kinome require, at some point, the visualizatio...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2012
ISSN: 1664-042X
DOI: 10.3389/fphys.2012.00438